1. Medicines for Malaria and Novartis successfully move ahead to phase 3 trial

According to the latest research and results, new studies have hoped their way as the world faces immense cures for the disease- malaria. Novartis and Medicines for Malaria Venture MMV  have announced that they have successfully passed trial two and are on their way to lead the ganaplacide/lumefantrine solid dispersion formulation (SDF) and promote it to enter phase 3 development. The method of cure is useful for the people who are suffering from acute malaria due to plasmodium falciparum and is research done to show the concerns and challenges in the treatment of malaria over to existing therapies.

Ganaplacide is a novel agent combined with the latest method, which is the once-daily formulation of lumefantrine. This combination has the ability to fight against malaria and get rid of the malaria infection completely – including artemisinin-resistant strains – while also stopping the transmission of the illness.

The trial is planned to be held by joining hands with the WANECAM 2 consortium and will welcome the partner clinical location in Burkina Faso, Mali, Gabon and Niger, and other areas in sub-Saharan Africa.

Dr. Sujata Vaidyanathan, global health development unit head, at Novartis, stated: “The combination of artemisinin resistance demands urgent response to develop new antimalarial treatments. We require non-artemisinin-based medicines that work on novel mechanisms against resistant parasites and simple, easy-to-follow dosing time table to increase treatment efficiency.”. “The quicker we have new treatment inaction and the faster the world accepts them, the better are the chances of beating the problem,” he added.

According to the World Malaria Report , in December 2021, there were approximately 241 million malaria patients and 627,000 deaths in the world in 2020 because of this significant disease.

1. Turbine shakes up the hand with AI platform to help in cancer treatments

Turbine, a company which is known for its development of a cell simulation platform, has completed a €20m financing circle. Mercia and MSD – also known as Merck & Co in the US and Canada – Global Health Innovation (GHI) Fund  have joined hands with the company in terms of finances, joined by Day One Capital and existing investors Accel, Delin Ventures and XTX Ventures.

The Simulated Cell Providing Company is now powered by artificial intelligence (AI) and can easily understand the deep-root problem, cure, and the overall treatment help that the patient receives against cancer. They plan to expand with respect to the team and welcome new partnerships with biopharmaceutical companies.

“MSD GHI looks forward to accelerating Turbine’s growth and spread,” said David Rubin, managing director – MSD GHI Fund. “We have a thought that Turbine’s Simulated Cell has the calibre to change the major aspects of the oncology drug discovery and making process, providing insight at the scale that will throw light on even the most problematic biological mechanisms of the body.”

“The idea rise from our concern that experiments have led us to make more expensive and time-consuming concequenses when we think about drug development failures,” stated Szabolcs Nagy, chief executive officer at Turbine. “After all the thoughts, since 2016 limited biologists and data scientists were there to encourage the technologies and to judge the experiments better after understanding the impact of the experients on the patients and more likely to make it understandable in the clinic.”

Daniela Tsoneva of Mercia stated, “Turbine technology reveals historic problems and troubles to drug development and is already progressive by early work with huge pharma partners shaking hands. We are amused to join hands with the company as it progresses its platform, comes to a mutual understanding on the cancer biology, and helps to make drug development more efficient and more successful across the biopharma industry.”

1. NICE is sure about Sobi’s Doptelet for thrombocytopenia treatment

Sobi has stated that the National Institute for Health and Care Excellence (NICE)  have confirmed the Final Appraisal Document in England and Wales, showing trust in the use of Doptelet.

Also known as avatrombopag, the treatment is usually given to adults with primary chronic immune thrombocytopenia (ITP) who are tired of other therapies, such as corticosteroids or immunoglobulins. The appraisal is a response from both sides, a randomized phase 3 study with open-label extension and two sequential steps two analyses. This research was done to understand the efficiency and safety of avatrombopag as a treatment for adults with primary ITP.

During the procedure, the patients have been given one or more therapies for ITP to observe the results keenly. Out of the 49 patients, Doptelet was the best therapy to overcome the primary last point of the cumulative number of weeks of platelet response.

Dr. Drew Provan, a Consultant Haematologist at Barts and The London School of Medicine and Dentistry, said: “The commensement of the TPO-RAs, as a proper law of treatment, has transformed the ITP management landscape significantly, helping us to reduce the immune suppression, especially during the crisis. Avatrombopag has no specific food-type restrictions and as such no routine liver function monitoring, and no need for dose reduction in Asian people who are suffering.”

Mervyn Morgan, CEO of the UK and Ireland Patient Support Organisation for Immune Thrombocytopenia, also added: “Chronic ITP is a burdensome long-term problem with many facing fatigue levels that impact their everyday life. Some patients prefer oral treatments with fewer dietary follow ups, so having varied treatment alternatives is crucial. I am gratified that ITP patients in England and Wales now have good hold to avatrombopag, like patients in Scotland and other parts of Europe.”

Doptelet is now approved and given to patients in Scotland for the treatment of ITP.

1. A new ray of hope for patients with neurodegenerative disease

According to new research, scientists have discovered a well-planned treatment that can help to slow the increase of neurodegenerative disease in mice. The breakthrough research is an excellent sign to control some of the untreatable conditions such as Alzheimer’s disease (AD).

The study, which is analyzed and researched at the University of Glasgow’s new Advanced Research Centre (ARC), came to the conclusion that using a novel drug that selectively activates a brain protein called the M1 receptor is good for the lifespan of mice suffering from neurodegeneration, as it was observed that eventually, the lifespan increased. Currently, treatments for AD are only under the target symptoms, including memory impairment, and previous drugs and medications that can slow down the disease have been unsuccessful.

However, the drug emerging after almost a decade of research from the teams at Vanderbilt University in Nashville, Tennessee, and the University of Glasgow is really a good hope for the patients. Meanwhile, The Vanderbilt University team is still examining an M1-PAM in humans as a treatment for memory loss in AD patients.

Dr. Sophie Bradley, an honorary senior researcher at the University of Glasgow and co-corresponding author, shared: “This study is acknowledge further to enable to the rationale for targeting M1 muscarinic acetylcholine receptors in neurodegenerative problems, such as AD, and increases the chances that this target may mediate disease-modifying outcomes as well as can improve signs and symptoms along with triggers that are associated with the disease.”

Andrew Tobin, professor of molecular pharmacology at the University of Glasgow, said: “The world actually require alternatives and answers to stop neurodegenerative issues like AD – and our study is of great help as we deliver that many of the consequences of the problem that are observed in our animal model can be used by our drug treatment.”

AD is an actual problem in most nations and is most common forms of neurodegenerative disease spreading to more than 850,000 people in the UK and over 55 million across the world.